WEE2 Antikörper

Produktnummer ABIN7076224

Produktdetails anti-WEE2 Antikörper

Target: WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WEE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse WEE2

Anwendungsinformationen

Applikationshinweise: WB (H) 1:300-1:600

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu WEE2

Target: WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))

Andere Bezeichnung: WEE2 (WEE2 Produkte)

Synonyme: Xe-wee1 antikoerper, wee1 antikoerper, wee1-b antikoerper, wee1a antikoerper, wee1b antikoerper, wee2-b antikoerper, xwee1 antikoerper, xwee2 antikoerper, WEE1B antikoerper, Gm1065 antikoerper, Wee1B antikoerper, WEE2 antikoerper, im:5913035 antikoerper, si:ch211-238n5.5 antikoerper, wu:fi13b10 antikoerper, zgc:123074 antikoerper, WEE1 homolog 2 antikoerper, WEE1 homolog 2 (S. pombe) antikoerper, wee2 antikoerper, WEE2 antikoerper, Wee2 antikoerper

Hintergrund: WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.

Molekulargewicht: 62 kDa

Gen-ID: 381759

UniProt: Q66JT0

Pathways: M Phase