MAML1 Antikörper

Produktnummer ABIN7074560

Produktdetails anti-MAML1 Antikörper

Target: MAML1 (Mastermind-Like 1 (MAML1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAML1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse MAML1

Anwendungsinformationen

Applikationshinweise: WB (H,M) 1: 500-1: 1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Andere Bezeichnung: MAML1 (MAML1 Produkte)

Synonyme: mam1 antikoerper, mam-1 antikoerper, xmam1 antikoerper, MAML1 antikoerper, AI644666 antikoerper, AW743257 antikoerper, D930008C07Rik antikoerper, Mam-1 antikoerper, Mam1 antikoerper, mKIAA0200 antikoerper, mastermind like transcriptional coactivator 1 L homeolog antikoerper, mastermind like transcriptional coactivator 1 antikoerper, mastermind like 1 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 1 antikoerper, maml1.L antikoerper, MAML1 antikoerper, Maml1 antikoerper

Hintergrund: MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.

Molekulargewicht: 130 kDa

Gen-ID: 103806

NCBI Accession: NP_780543

UniProt: Q6T264

Pathways: Notch Signalweg, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development