FMO3 Antikörper

Produktnummer ABIN7259921

Produktdetails anti-FMO3 Antikörper

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FMO3 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human FMO3 (NP_001002294.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Andere Bezeichnung: FMO3 (FMO3 Produkte)

Synonyme: MGC107820 antikoerper, FMOII antikoerper, TMAU antikoerper, dJ127D3.1 antikoerper, FM03 antikoerper, AW111792 antikoerper, flavin containing monooxygenase 3 antikoerper, flavin containing monooxygenase 3 L homeolog antikoerper, FMO3 antikoerper, fmo3 antikoerper, fmo3.L antikoerper, Fmo3 antikoerper

Hintergrund: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Gen-ID: 2328

UniProt: P31513