F13A1 Antikörper
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- Target Alle F13A1 Antikörper anzeigen
- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser F13A1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human F13A1 (NP_000120.2).
- Isotyp
- IgG
- Top Product
- Discover our top product F13A1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
- Andere Bezeichnung
- F13A1 (F13A1 Produkte)
- Synonyme
- F13a antikoerper, f13a1 antikoerper, wu:fo83d04 antikoerper, zgc:153334 antikoerper, F13A1 antikoerper, F13A antikoerper, 1200014I03Rik antikoerper, AI462306 antikoerper, coagulation factor XIII A1 chain antikoerper, coagulation factor XIII, A1 polypeptide b antikoerper, coagulation factor XIII A chain antikoerper, coagulation factor XIII, A1 subunit antikoerper, F13a1 antikoerper, f13a1b antikoerper, F13A1 antikoerper
- Hintergrund
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
- Molekulargewicht
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Observed_MW: 83 kDa
Calculated_MW: 83 kDa
- Gen-ID
- 2162
- UniProt
- P00488
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