Aminoacylase 1 Antikörper

Produktnummer ABIN7257008

Produktdetails anti-Aminoacylase 1 Antikörper

Target: Aminoacylase 1 (ACY1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aminoacylase 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human ACY1 (NP_001185824.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200 IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Aminoacylase 1

Target: Aminoacylase 1 (ACY1)

Andere Bezeichnung: ACY1 (ACY1 Produkte)

Synonyme: si:zfos-226g1.1 antikoerper, zgc:55605 antikoerper, zgc:76955 antikoerper, acy1 antikoerper, acy1d antikoerper, acylase antikoerper, ACY1 antikoerper, ACY-1 antikoerper, ACY1D antikoerper, 1110014J22Rik antikoerper, Acy-1 antikoerper, Acy1a antikoerper, Acy1b antikoerper, aminoacylase 1 antikoerper, aminoacylase 1, gene 1 S homeolog antikoerper, aminoacylase 1, gene 1 antikoerper, ACY1 antikoerper, acy1 antikoerper, acy1.1.S antikoerper, acy1.1 antikoerper, Acy1 antikoerper

Hintergrund: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Gen-ID: 95

UniProt: Q03154