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Aminoacylase 1 Produkte

(Aminoacylase 1 (ACY1))

Kategorien

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010].

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Ausgewählte Aminoacylase 1 Kategorien

Aminoacylase 1 Antikörper

High quality antibodies with extensive validation data.

Aminoacylase 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Aminoacylase 1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Aminoacylase 1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (6)
Kat. Nr. ABIN7434791
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Dog, Human, Mouse, Rat
Applikation WB, IHC, FACS, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN1496452
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Dog, Human, Monkey
Applikation WB, IHC, FACS, IHC (p)
Validierungen
  • (12)
Kat. Nr. ABIN1496455
Menge 100 μL
Datenblatt Datenblatt

Empfohlene Aminoacylase 1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6953660
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4881733
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1121512
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Aminoacylase 1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7121810
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7121809
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN7320441
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Aminoacylase 1 Produkten

Jansen, van Rijswijk, Teubel, van Weerden, Reneman, van den Bemd, Roobol, Bangma, Staal, Jenster: "Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers." in: Journal of proteome research, Vol. 11, Issue 2, pp. 728-35, (2012) (PubMed).

Sommer, Christensen, Schwenger, Seul, Haas, Olbrich, Omran, Sass: "The molecular basis of aminoacylase 1 deficiency." in: Biochimica et biophysica acta, Vol. 1812, Issue 6, pp. 685-90, (2011) (PubMed).

Cigna, Nicoletti, Durand, Chaix, Giardina, Perrier: "Acylase 1 expression in rat intestinal crypt--villus axis." in: Cell biology international, Vol. 31, Issue 9, pp. 966-73, (2007) (PubMed).

Van Coster, Gerlo, Giardina, Engelke, Smet, De Praeter, Meersschaut, De Meirleir, Seneca, Devreese, Leroy, Herga, Perrier, Wevers, Lissens: "Aminoacylase I deficiency: a novel inborn error of metabolism." in: Biochemical and biophysical research communications, Vol. 338, Issue 3, pp. 1322-6, (2005) (PubMed).

Synonyme und alternative Namen zu Aminoacylase 1

aminoacylase 1 (ACY1), aminoacylase 1 (acy1), aminoacylase 1, gene 1 S homeolog (acy1.1.S), aminoacylase 1, gene 1 (acy1.1), aminoacylase 1 (Acy1), 1110014J22Rik, ACY-1, Acy-1, acy1, ACY1, Acy1a, Acy1b, acy1d, ACY1D, acylase, si:zfos-226g1.1, zgc:55605, zgc:76955

Bezeichner auf Proteinebene für Aminoacylase 1

  • aminoacylase-1
  • aminoacylase 1
  • N-acyl-L-amino-acid amidohydrolase
  • acylase
  • ACY IA
  • ACY IB
  • ACY-1A
  • ACY-1B
  • aminoacylase-1A
  • aminoacylase-1B
  • ACY-1
  • N-acylamino acid aminohydrolase (Aminoacylase 1)
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