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ERK1/2 Antikörper (pTyr205, pTyr222)

MAPK1/3 Reaktivität: Human, Maus, Ratte IHC (p) Wirt: Maus Monoclonal 4D4 unconjugated
Produktnummer ABIN7005808
  • Target Alle ERK1/2 (MAPK1/3) Antikörper anzeigen
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    Bindungsspezifität
    • 56
    • 41
    • 30
    • 30
    • 16
    • 12
    • 12
    • 10
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr205, pTyr222
    Reaktivität
    • 199
    • 169
    • 166
    • 22
    • 22
    • 18
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 143
    • 58
    • 4
    Maus
    Klonalität
    • 139
    • 66
    Monoklonal
    Konjugat
    • 99
    • 12
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Dieser ERK1/2 Antikörper ist unkonjugiert
    Applikation
    • 157
    • 65
    • 51
    • 51
    • 49
    • 38
    • 24
    • 23
    • 22
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Produktmerkmale
    Phosphorylated antibody
    Aufreinigung
    Protein A purification
    Immunogen
    Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)
    Klon
    4D4
    Isotyp
    IgG
    Top Product
    Discover our top product MAPK1/3 Primärantikörper
  • Applikationshinweise
    IHC 1:100-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    Andere Bezeichnung
    ERK 1/2 (MAPK1/3 Produkte)
    Synonyme
    erk1/2 antikoerper, mitogen-activated protein kinase antikoerper, erk1/2 antikoerper
    Hintergrund
    Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1, required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
    UniProt
    P27361, P28482
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