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beta Catenin Antikörper (pSer37)

Name: beta Catenin Antikörper (pSer37)
Brand: antibodies-online
SKU: ABIN7250713
Price: 449 EUR
Availability: InStock

CATNB Reaktivität: Human, Maus, Ratte WB, IF, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

Western Blot analysis of 293T cells using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:2000 (beta Catenin Antikörper (pSer37))

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:200 (beta Catenin Antikörper (pSer37))

IHC (p)

Immunofluorescence analysis of Human kidney tissue using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:200 (beta Catenin Antikörper (pSer37))

3 Abbildungen

Produktnummer ABIN7250713

Datenblatt (PDF)

Target Alle beta Catenin (CATNB) Antikörper anzeigen

beta Catenin (CATNB) (Catenin, beta (CATNB))
Bindungsspezifität
43

27

21

20

20

17

17

17

17

16

16

15

9

8

7

7

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer37
Reaktivität
330

247

225

29

23

22

18

18

5

5

5

5

1

1

1

1

1

1

1

1
Human, Maus, Ratte
Wirt
270

59

4

2

1
Kaninchen
Passende Sekundärantikörper
Klonalität
265

71
Polyklonal
Konjugat
122

22

16

15

15

15

15

15

11

10

9

9

9

9

9

8

4

4

4

4

4

4

1

1

1
Dieser beta Catenin Antikörper ist unkonjugiert
Applikation
206

158

120

118

73

62

61

48

35

31

22

8

7

4

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktmerkmale

Phosphorylated antibody

Aufreinigung

Affinity purification

Immunogen

Synthesized peptide derived from human Catenin-beta around the phosphorylation site of Ser37

Isotyp

IgG

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Applikationshinweise

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20°C. Avoid freeze / thaw cycles.
Target

beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung

Catenin beta (CATNB Produkte)

Synonyme

Bfc antikoerper, Catnb antikoerper, Mesc antikoerper, CTNNB antikoerper, MRD19 antikoerper, armadillo antikoerper, ctnnb antikoerper, id:ibd2058 antikoerper, wu:fb73e10 antikoerper, wu:fi81c06 antikoerper, wu:fk25h01 antikoerper, beta-catenin antikoerper, ctnnb1 antikoerper, CHBCAT antikoerper, catenin (cadherin associated protein), beta 1 antikoerper, catenin beta 1 antikoerper, catenin (cadherin-associated protein), beta 1 antikoerper, catenin beta 1 L homeolog antikoerper, Ctnnb1 antikoerper, CTNNB1 antikoerper, ctnnb1 antikoerper, ctnnb1.L antikoerper

Hintergrund

Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Molekulargewicht

Observed_MW: 85 kDa
Calculated_MW: 85 kDa

UniProt

P35222

Pathways

Peptide Hormone Metabolism