SRPK2 Antikörper

Produktnummer ABIN7247336

Produktdetails anti-SRPK2 Antikörper

Target: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRPK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human SRPK2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-1:300, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.56 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SRPK2

Target: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Andere Bezeichnung: SRPK2 (SRPK2 Produkte)

Synonyme: SFRSK2 antikoerper, AW226533 antikoerper, AW492537 antikoerper, AW547358 antikoerper, Wbp6 antikoerper, mSRPK2 antikoerper, sfrsk2 antikoerper, srpk2 antikoerper, srpk2-b antikoerper, srpk2b antikoerper, SRSF protein kinase 2 antikoerper, serine/arginine-rich protein specific kinase 2 antikoerper, SRSF protein kinase 2 L homeolog antikoerper, SRPK2 antikoerper, Srpk2 antikoerper, srpk2 antikoerper, srpk2.L antikoerper

Hintergrund: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

UniProt: P78362

Pathways: Ribonucleoprotein Complex Subunit Organization