WNT5B Antikörper (AA 130-180)

Produktnummer ABIN6992093

Produktdetails anti-WNT5B Antikörper

Target: WNT5B (Wingless-Type MMTV Integration Site Family, Member 5B (WNT5B))

Bindungsspezifität: AA 130-180

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WNT5B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: WNT5 antibody is human, mouse and rat reactive. WNT5 antibody will detect both WNT5A and WNT5B. At least two isoforms of WNT5B are known to exist, this antibody will detect both isoforms.

Aufreinigung: WNT5 antibody is affinity chromatography purified via peptide column.

Immunogen: WNT5 antibody was raised against a 15 amino acid peptide near the center of human WNT5B. The immunogen is located within amino acids 130 - 180 of WNT5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WNT5 antibody can be used for detection of WNT5 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: WNT5 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: WNT5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu WNT5B

Target: WNT5B (Wingless-Type MMTV Integration Site Family, Member 5B (WNT5B))

Andere Bezeichnung: WNT5 (WNT5B Produkte)

Synonyme: wnt-5b antikoerper, xwnt5b antikoerper, WNT5B antikoerper, AW545702 antikoerper, Wnt-5b antikoerper, xwnt-5c antikoerper, CHUNP6928 antikoerper, id:ibd5111 antikoerper, ppt antikoerper, wnt-5 antikoerper, wnt5 antikoerper, wnt[b] antikoerper, wu:fk85g06 antikoerper, Wnt family member 5B antikoerper, wingless-type MMTV integration site family, member 5B antikoerper, Wnt family member 5B S homeolog antikoerper, wingless-type MMTV integration site family, member 5b antikoerper, wnt5b antikoerper, WNT5B antikoerper, Wnt5b antikoerper, wnt5b.S antikoerper

Hintergrund: WNT5A and WNT5B are near-identical members of the WNT gene family, which consists of structurally related genes which encode secreted signaling proteins that have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis (1,2). WNT5A and WNT5B coordinate chondrocyte proliferation and differentiation by differentially regulating cyclin D1 and p130 expression, as well as chondrocyte-specific Col2a1 expression (3). Up-regulation of WNT5A and WNT5B has been observed in several types of human cancers, suggesting that they may be useful as diagnostic markers or potent therapeutic targets (4).

Molekulargewicht: Predicted: 39 kDa

Observed: 465 kDa

Gen-ID: 81029

NCBI Accession: NP_110402

UniProt: Q9H1J7

Pathways: WNT Signalweg, Embryonic Body Morphogenesis, Positive Regulation of fat Cell Differentiation