APBA1 Antikörper (N-Term)

Produktnummer ABIN6991712

Produktdetails anti-APBA1 Antikörper

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Bindungsspezifität: AA 90-140, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APBA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Spezifität: At least two alternatively spliced isoforms are known to exist, this antibody will detect both isoforms. This antibody is predicted to not cross-react with other APBA proteins.

Aufreinigung: APBA1 Antibody is affinity chromatography purified via peptide column.

Immunogen: APBA1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human APBA1. The immunogen is located within amino acids 90 - 140 of APBA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: APBA1 antibody can be used for detection of APBA1 by Western blot at 0.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: APBA1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: APBA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu APBA1

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Andere Bezeichnung: APBA1 (APBA1 Produkte)

Synonyme: APBA1 antikoerper, 6430513E09Rik antikoerper, Lin-10 antikoerper, Mint antikoerper, Mint1 antikoerper, Urop11 antikoerper, X11 antikoerper, X11alpha antikoerper, D9S411E antikoerper, LIN10 antikoerper, MINT1 antikoerper, X11A antikoerper, X11ALPHA antikoerper, amyloid beta precursor protein binding family A member 1 antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1b antikoerper, ketopantoate reductase antikoerper, 2-dehydropantoate 2-reductase antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 1 antikoerper, amyloid beta (A4) precursor protein binding, family A, member 1 antikoerper, APBA1 antikoerper, apba1b antikoerper, apbA1 antikoerper, apba1 antikoerper, Apba1 antikoerper

Hintergrund: APBA1 Antibody: The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). APBA1 stabilizes APP and inhibits production of proteolytic APP fragments including the Aβ, peptide that is deposited in the brains of Alzheimer's disease patients. It is thought to be involved in signal transduction processes and is a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. APBA1 can also bind to CASK, a multidomain scaffolding protein involved in brain development and synapse formation.

Molekulargewicht: Predicted: 92 kDa

Observed: 92 kDa

Gen-ID: 320

NCBI Accession: NP_001154

UniProt: Q02410

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport