SDHD Antikörper (AA 30-80)

Produktnummer ABIN6991691

Produktdetails anti-SDHD Antikörper

Target: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Bindungsspezifität: AA 30-80

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SDHD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: At least four isoforms of SDHD are known to exist, this antibody will detect the two longest isoforms.

Aufreinigung: SDHD Antibody is affinity chromatography purified via peptide column.

Immunogen: SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD. The immunogen is located within amino acids 30 - 80 of SDHD.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SDHD antibody can be used for detection of SDHD by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SDHD Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SDHD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SDHD

Target: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Andere Bezeichnung: SDHD (SDHD Produkte)

Synonyme: RATSDHE1 antikoerper, SDH2 antikoerper, Sdh antikoerper, Sdhe1 antikoerper, TDH antikoerper, 3110001M13Rik antikoerper, AVLL5809 antikoerper, C78570 antikoerper, PRO19626 antikoerper, CII-4 antikoerper, CII4 antikoerper, QPs3 antikoerper, cybS antikoerper, CybS antikoerper, CBT1 antikoerper, CWS3 antikoerper, PGL antikoerper, PGL1 antikoerper, SDH4 antikoerper, MSN2.16 antikoerper, MSN2_16 antikoerper, succinate dehydrogenase 1-1 antikoerper, CybS-B antikoerper, cbt1 antikoerper, pgl antikoerper, pgl1 antikoerper, sdh4 antikoerper, cybS-B antikoerper, sdhd antikoerper, sdhda antikoerper, zgc:100986 antikoerper, serine dehydratase antikoerper, succinate dehydrogenase complex, subunit D, integral membrane protein antikoerper, succinate dehydrogenase complex subunit D antikoerper, succinate dehydrogenase 1-1 antikoerper, succinate dehydrogenase complex subunit D, integral membrane protein L homeolog antikoerper, succinate dehydrogenase complex, subunit D, integral membrane protein b antikoerper, Sds antikoerper, Sdhd antikoerper, SDHD antikoerper, SDH1-1 antikoerper, sdhd.L antikoerper, sdhdb antikoerper

Hintergrund: SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

Gen-ID: 9392

NCBI Accession: NP_002993

UniProt: O14521