SDHD Antikörper (Middle Region)

Produktnummer ABIN1449927

Produktdetails anti-SDHD Antikörper

Target: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SDHD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the center of Human SDHD

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SDHD

Target: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Andere Bezeichnung: SDHD (SDHD Produkte)

Synonyme: RATSDHE1 antikoerper, SDH2 antikoerper, Sdh antikoerper, Sdhe1 antikoerper, TDH antikoerper, 3110001M13Rik antikoerper, AVLL5809 antikoerper, C78570 antikoerper, PRO19626 antikoerper, CII-4 antikoerper, CII4 antikoerper, QPs3 antikoerper, cybS antikoerper, CybS antikoerper, CBT1 antikoerper, CWS3 antikoerper, PGL antikoerper, PGL1 antikoerper, SDH4 antikoerper, MSN2.16 antikoerper, MSN2_16 antikoerper, succinate dehydrogenase 1-1 antikoerper, CybS-B antikoerper, cbt1 antikoerper, pgl antikoerper, pgl1 antikoerper, sdh4 antikoerper, cybS-B antikoerper, sdhd antikoerper, sdhda antikoerper, zgc:100986 antikoerper, serine dehydratase antikoerper, succinate dehydrogenase complex, subunit D, integral membrane protein antikoerper, succinate dehydrogenase complex subunit D antikoerper, succinate dehydrogenase 1-1 antikoerper, succinate dehydrogenase complex subunit D, integral membrane protein L homeolog antikoerper, succinate dehydrogenase complex, subunit D, integral membrane protein b antikoerper, Sds antikoerper, Sdhd antikoerper, SDHD antikoerper, SDH1-1 antikoerper, sdhd.L antikoerper, sdhdb antikoerper

Hintergrund: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.Synonyms: CII-4, CybS, QPs3, SDH4, Succinate dehydrogenase [ubiquinone] cytochrome b small subunit mitochondrial, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor subunit

Gen-ID: 6392

NCBI Accession: NP_002993