CLEC7A Antikörper (AA 70-120)

Produktnummer ABIN6991687

Produktdetails anti-CLEC7A Antikörper

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Bindungsspezifität: AA 70-120

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLEC7A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: Multiple isoforms of CLEC7A are known to exist.

Aufreinigung: CLEC7A Antibody is affinity chromatography purified via peptide column.

Immunogen: CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A. The immunogen is located within amino acids 70 - 120 of CLEC7A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CLEC7A antibody can be used for detection of CLEC7A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CLEC7A Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CLEC7A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CLEC7A

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Andere Bezeichnung: CLEC7A (CLEC7A Produkte)

Synonyme: CLEC7A antikoerper, BGR antikoerper, Clecsf12 antikoerper, beta-GR antikoerper, CANDF4 antikoerper, CLECSF12 antikoerper, DECTIN1 antikoerper, Clec7b antikoerper, RGD1565140 antikoerper, C-type lectin domain containing 7A antikoerper, C-type lectin domain family 7, member a antikoerper, CLEC7A antikoerper, Clec7a antikoerper

Hintergrund: CLEC7A Antibody: CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

Molekulargewicht: Predicted: 27 kDa

Observed: 27 kDa

Gen-ID: 64581

NCBI Accession: NP_922938

UniProt: Q9BXN2

Pathways: Activation of Innate immune Response