NLRP7 Antikörper (N-Term)

Produktnummer ABIN6991404

Produktdetails anti-NLRP7 Antikörper

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Bindungsspezifität: AA 90-140, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP7 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: NALP7 Antibody is affinity chromatography purified via peptide column.

Immunogen: NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NALP7 antibody can be used for detection of NALP7 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NALP7 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NALP7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NLRP7

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Andere Bezeichnung: NALP7 (NLRP7 Produkte)

Synonyme: CLR19.4 antikoerper, HYDM antikoerper, NALP7 antikoerper, NOD12 antikoerper, PAN7 antikoerper, PYPAF3 antikoerper, NLR family pyrin domain containing 7 antikoerper, NLRP7 antikoerper

Hintergrund: NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β, secretion and is a feedback regulator of interleukin-1β, secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Gen-ID: 199713

NCBI Accession: NP_631915

UniProt: Q8WX94

Pathways: Inflammasome