SKA1 Antikörper (C-Term)

Produktnummer ABIN6991190

Produktdetails anti-SKA1 Antikörper

Target: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Bindungsspezifität: AA 180-230, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKA1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: SKA1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SKA1 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human SKA1. The immunogen is located within amino acids 180 - 230 of SKA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SKA1 antibody can be used for detection of SKA1 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SKA1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SKA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SKA1

Target: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Andere Bezeichnung: SKA1 (SKA1 Produkte)

Synonyme: C18H18orf24 antikoerper, C18orf24 antikoerper, 2810433K01Rik antikoerper, AV117428 antikoerper, RGD1310784 antikoerper, spindle and kinetochore associated complex subunit 1 antikoerper, SKA1 antikoerper, ska1 antikoerper, Ska1 antikoerper

Hintergrund: SKA1 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.

Gen-ID: 220134

UniProt: Q96BD8

Pathways: M Phase