C-JUN Antikörper (AA 231-331) (AbBy Fluor® 488)

Produktnummer ABIN6977745

Dieses Anti-C-JUN-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von C-JUN in FACS. Geeignet für Human.

Kurzübersicht für C-JUN Antikörper (AA 231-331) (AbBy Fluor® 488) (ABIN6977745)

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C-JUN Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-C-JUN Antikörper (AbBy Fluor® 488)

Bindungsspezifität: AA 231-331

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C-jun

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu C-JUN

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Andere Bezeichnung: C-jun

Hintergrund:

Synonyms: Transcription factor AP-1, Jun oncogene, JUN, AP 1, AP1, AP-1, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN protein, JUNC, p39, Proto oncogene cJun, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, vJun Avian Sarcoma Virus 17 Oncogene Homolog, JUN_HUMAN, Activator 1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog.

Background: The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Gen-ID: 3725

UniProt: P05412

Pathways: MAPK Signalweg, RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteine