NR0B1 Antikörper (AA 135-166)

Produktnummer ABIN6971572

Produktdetails anti-NR0B1 Antikörper

Target: NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1))

Bindungsspezifität: AA 135-166

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NR0B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktmerkmale: DAX-1 (DSS-AHC critical region on the X chromosome protein 1, NR0B1, Nuclear receptor subfamily 0 group B member 1) is an orphan nuclear receptor and a component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. DAX-1 / NR0B1 inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. It may also have a role in embryonic development and in the maintenance of embryonic stem cell pluripotency as it up-regulates Oct-4 expression ES cells. Defects in DAX-1 are a cause of dosage-sensitive sex reversal (DSSR) and X-linked adrenal hypoplasia congenital (XL-AHC). DSSR results from a duplication of the region of the X-chromosome containing DAX-1, resulting in males with two copies of DAX-1, which inhibits normal testis formation, and thus XY individuals develop as females. XL-AHC is a developmental disorder of the adrenal gland, characterized by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. DAX-1 / NR0B1 antibody (mAb) (Clone 1DA-2F4) was raised in a Mouse host. It has been validated for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western blot, it has been shown to react with Human, Mouse and Rat samples.

Aufreinigung: Protein A Chromatography

Immunogen: This DAX-1 / NR0B1 antibody was raised against a peptide corresponding to amino acids 135-166 of human DAX-1 / NR0B1.

Klon: 1DA-2F4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 60 mM Sodium Citrate, 105 mM Tris-HCl, 30 % glycerol, and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu NR0B1

Target: NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1))

Andere Bezeichnung: DAX-1 / NR0B1 (NR0B1 Produkte)

Synonyme: DAX antikoerper, NR0B1 antikoerper, dax1 antikoerper, AHC antikoerper, AHCH antikoerper, AHX antikoerper, DAX-1 antikoerper, DAX1 antikoerper, DSS antikoerper, GTD antikoerper, HHG antikoerper, NROB1 antikoerper, SRXY2 antikoerper, Ahc antikoerper, Ahch antikoerper, Dax1 antikoerper, nuclear receptor subfamily 0 group B member 1 antikoerper, nuclear receptor subfamily 0, group B, member 1 antikoerper, nuclear receptor subfamily 0 group B member 1 L homeolog antikoerper, NR0B1 antikoerper, nr0b1 antikoerper, nr0b1.L antikoerper, Nr0b1 antikoerper

Molekulargewicht: 52 kDa

NCBI Accession: NP_000466

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling