SRP54 Antikörper

Produktnummer ABIN6945061

Produktdetails anti-SRP54 Antikörper

Target: SRP54 (Signal Recognition Particle 54kDa (SRP54))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SRP54 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human SRP54 aa 1-200.

Klon: 1A4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IP(1-2 μg)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SRP54

Target: SRP54 (Signal Recognition Particle 54kDa (SRP54))

Andere Bezeichnung: SRP54 (SRP54 Produkte)

Synonyme: Srp54k antikoerper, zgc:55842 antikoerper, zgc:85713 antikoerper, SRP54 antikoerper, signal recognition particle 54 antikoerper, signal recognition particle protein antikoerper, signal recognition particle subunit Srp54 antikoerper, signal recognition particle antikoerper, family with sequence similarity 177 member A1 antikoerper, signal recognition particle 54kDa S homeolog antikoerper, signal recognition particle 54kDa antikoerper, SRP54 antikoerper, srp54 antikoerper, SSO_RS04840 antikoerper, MA_RS23935 antikoerper, AF_RS03170 antikoerper, PAB_RS02540 antikoerper, MSP_RS07670 antikoerper, RCI_RS04175 antikoerper, TGAM_RS09885 antikoerper, MTBMA_RS08340 antikoerper, FAM177A1 antikoerper, srp54.S antikoerper, Srp54 antikoerper

Hintergrund:

Synonyms: Signal recognition particle 54 kDa protein, SRP54

Background: SRP54, a component of the signal recognition particle (SRP), recognizes the signal peptide of secretory proteins and interacts with the signal recognition particle receptor to target the ribosome and the associated nascent chain to the endoplasmic reticulum. By functional analysis showed that SRP54 binds to SRP RNA via the M-domain, but only in the presence of RNA-bound SRP19, and that it associates with the signal peptide of nascent polypeptide chains. RNA interaction requires the presence of a loop in the C-terminal M-domain. Signal peptide recognition most likely involves methionine-rich loops. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts the signal recognition particle receptor, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.

Gen-ID: 6729

UniProt: P61011

Pathways: SARS-CoV-2 Protein Interaktom