DKC1 Antikörper

Produktnummer ABIN6943003

Produktdetails anti-DKC1 Antikörper

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser DKC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human DKC1 aa 300-450

Klon: 5C7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Andere Bezeichnung: DKC1 (DKC1 Produkte)

Synonyme: CBF5 antikoerper, DKC antikoerper, DKCX antikoerper, NAP57 antikoerper, NOLA4 antikoerper, XAP101 antikoerper, dyskerin antikoerper, fv62a07 antikoerper, wu:fa28f10 antikoerper, wu:fc87a02 antikoerper, wu:fi24a05 antikoerper, wu:fv62a07 antikoerper, zgc:110395 antikoerper, DKC1 antikoerper, cbf5 antikoerper, dkc antikoerper, nap57 antikoerper, nola4 antikoerper, xap101 antikoerper, BC068171 antikoerper, Nap57 antikoerper, AtCBF5 antikoerper, AtNAP57 antikoerper, homologue of NAP57 antikoerper, dyskerin pseudouridine synthase 1 antikoerper, microRNA 664b antikoerper, dyskeratosis congenita 1, dyskerin antikoerper, dyskeratosis congenita 1, dyskerin L homeolog antikoerper, homologue of NAP57 antikoerper, DKC1 antikoerper, MIR664B antikoerper, dkc1 antikoerper, dkc1.L antikoerper, Dkc1 antikoerper, NAP57 antikoerper

Hintergrund:

Synonyms: H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, dyskerin pseudouridine synthase 1, NOLA4.

Background: Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).

Gen-ID: 1736

UniProt: O60832

Pathways: Telomere Maintenance