Rekombinanter CD21 Antikörper (AA 44-196)
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- Target Alle CD21 (CR2) Antikörper anzeigen
- CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- AA 44-196
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD21 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Staining Methods (StM)
- Spezifität
- Recognizes a protein of 140 kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant fragment (around aa 44-196) of human CR2 (CD21) protein (exact sequence is proprietary)
- Klon
- RCR2-1952
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CR2 Primärantikörper
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- Applikationshinweise
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Positive Control: WEHI-231 cells. Human tonsil (IHC).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))
- Andere Bezeichnung
- CR2 (CR2 Produkte)
- Synonyme
- C3DR antikoerper, CD21 antikoerper, CR antikoerper, CVID7 antikoerper, SLEB9 antikoerper, Cd21 antikoerper, cd21 antikoerper, CR1 antikoerper, CR1-L antikoerper, CR2 antikoerper, complement C3d receptor 2 antikoerper, complement C3b/C4b receptor 1 (Knops blood group) antikoerper, CR2 antikoerper, Cr2 antikoerper, CR1 antikoerper
- Molekulargewicht
- 140kDa
- Gen-ID
- 1380
- UniProt
- P20023
- Pathways
- Komplementsystem
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