CGA Antikörper

Produktnummer ABIN6939100

Produktdetails anti-CGA Antikörper

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CGA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)

Spezifität: This MAb reacts with a protein of ~13 kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length hLH alpha protein

Klon: LHa-756

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Anterior Pituitary.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(No special pre-treatment is required for staining of formalin-fixed tissues. Note that HIER is NOT recommended for this antibody.)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CGA

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Andere Bezeichnung: LHA (CGA Produkte)

Synonyme: CG-ALPHA antikoerper, FSHA antikoerper, GPHA1 antikoerper, GPHa antikoerper, HCG antikoerper, LHA antikoerper, TSHA antikoerper, CG-alpha antikoerper, GPHalpha antikoerper, Tsha antikoerper, aGSU antikoerper, alpha-GSU antikoerper, alphaGSU antikoerper, alphaSU antikoerper, CGA antikoerper, FSH-alpha antikoerper, LSH-alpha antikoerper, TSH-alpha antikoerper, cg-alpha antikoerper, cga antikoerper, cga-a antikoerper, cga-b antikoerper, fsha antikoerper, gpha antikoerper, gpha1 antikoerper, hcg antikoerper, lha antikoerper, tsha antikoerper, GTH-alpha antikoerper, gsu-alpha antikoerper, glycoprotein hormones, alpha polypeptide antikoerper, glycoprotein hormones, alpha subunit antikoerper, chromogranin A antikoerper, glycoprotein hormones, alpha polypeptide L homeolog antikoerper, CGA antikoerper, Cga antikoerper, CHGA antikoerper, cga.L antikoerper, cga antikoerper

Molekulargewicht: ~13kDa

Gen-ID: 1081

UniProt: P01215

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism