MAGEA1 Antikörper
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- Target Alle MAGEA1 Antikörper anzeigen
- MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MAGEA1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
- Kreuzreaktivität (Details)
- Human. Rat. Dog.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human MAGE-A1 protein
- Klon
- MA454
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product MAGEA1 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Melanoma cell lines. Melanomas or testicular carcinomas.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))
- Andere Bezeichnung
- MAGEA1 (MAGEA1 Produkte)
- Synonyme
- CT1.1 antikoerper, MAGE1 antikoerper, Mage-a1 antikoerper, MAGE family member A1 antikoerper, melanoma antigen, family A, 1 antikoerper, MAGEA1 antikoerper, Magea1 antikoerper
- Hintergrund
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MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, MAGEA1, Melanoma antigen family A 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E,MAGE-1 (Target for Cancer Immunotherapy)
Cellular localisation: Cytoplasmic - Molekulargewicht
- 42-46kDa
- Gen-ID
- 4100, 72879
- UniProt
- P43355
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