MAGEA1 Antikörper

Produktnummer ABIN6940000

Produktdetails anti-MAGEA1 Antikörper

Target: MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))

Reaktivität: Human, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAGEA1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität: Recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length human MAGE-A1 protein

Klon: MA454

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Melanoma cell lines. Melanomas or testicular carcinomas.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu MAGEA1

Target: MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))

Andere Bezeichnung: MAGEA1 (MAGEA1 Produkte)

Synonyme: CT1.1 antikoerper, MAGE1 antikoerper, Mage-a1 antikoerper, MAGE family member A1 antikoerper, melanoma antigen, family A, 1 antikoerper, MAGEA1 antikoerper, Magea1 antikoerper

Molekulargewicht: 42-46kDa

Gen-ID: 4100

UniProt: P43355