BCMA Antikörper (AA 78-184)

Produktnummer ABIN6936646

Produktdetails anti-BCMA Antikörper

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Bindungsspezifität: AA 78-184

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCMA Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Klon: BCMA-2366

Isotyp: IgG2c kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu BCMA

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Andere Bezeichnung: CD269 (TNFRSF17 Produkte)

Synonyme: TNFRSF17 antikoerper, BCM antikoerper, BCMA antikoerper, CD269 antikoerper, TNFRSF13A antikoerper, Tnfrsf13 antikoerper, Tnfrsf13a antikoerper, TNF receptor superfamily member 17 antikoerper, tumor necrosis factor receptor superfamily, member 17 antikoerper, Tnfrsf17 antikoerper, TNFRSF17 antikoerper

Hintergrund: B-cell maturation protein, BCMA, CD269, TNR17, Tumor necrosis factor receptor superfamily member 17 (TNFRSF17),CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein)
Cellular localisation: Cell Surface

Molekulargewicht: 20kDa

Gen-ID: 608, 2556

UniProt: Q02223