C1QA Antikörper (AA 104-237)

Produktnummer ABIN6936537

Produktdetails anti-C1QA Antikörper

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Bindungsspezifität: AA 104-237

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C1QA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 104-237) of human C1QA protein (exact sequence is proprietary)

Klon: C1QA-2953

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human liver or kidney tissue (IHC). PC-3 cell lysate (WB).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu C1QA

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Andere Bezeichnung: C1QA (C1QA Produkte)

Synonyme: zgc:109903 antikoerper, C1QA antikoerper, AI255395 antikoerper, C1q antikoerper, complement C1q A chain antikoerper, complement component 1, q subcomponent, A chain antikoerper, complement component 1, q subcomponent, alpha polypeptide antikoerper, C1QA antikoerper, c1qa antikoerper, C1qa antikoerper

Hintergrund: Complement C1q subcomponent subunit A, Complement component 1 q subcomponent alpha polypeptide,C1QA / Complement C1q A-Chain
Cellular localisation: Secreted

Molekulargewicht: 29kDa

Gen-ID: 712, 632379

UniProt: P02745

Pathways: Komplementsystem