PAFAH1B1 Antikörper (AA 311-410) (Biotin)

Produktnummer ABIN676870

Produktdetails anti-PAFAH1B1 Antikörper (Biotin)

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Bindungsspezifität: AA 311-410

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAFAH1B1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LIS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PAFAH1B1

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Andere Bezeichnung: LIS1 (PAFAH1B1 Produkte)

Synonyme: LIS1 antikoerper, LIS2 antikoerper, MDCR antikoerper, MDS antikoerper, PAFAH antikoerper, LIS-1 antikoerper, Lis1 antikoerper, MMS10-U antikoerper, Mdsh antikoerper, Ms10u antikoerper, Pafaha antikoerper, lis2 antikoerper, mdcr antikoerper, mds antikoerper, pafah antikoerper, pafah1b1-b antikoerper, PAFAHA antikoerper, Lis1a antikoerper, platelet activating factor acetylhydrolase 1b regulatory subunit 1 antikoerper, platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 antikoerper, platelet activating factor acetylhydrolase 1b regulatory subunit 1 L homeolog antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a antikoerper, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b antikoerper, PAFAH1B1 antikoerper, Pafah1b1 antikoerper, pafah1b1.L antikoerper, pafah1b1a antikoerper, pafah1b1b antikoerper

Hintergrund:

Synonyms: MDS, LIS1, LIS2, MDCR, PAFAH, Platelet-activating factor acetylhydrolase IB subunit alpha, Lissencephaly-1 protein, LIS-1, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH alpha, PAFAH1B1, PAFAHA

Background: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Gen-ID: 5048

UniProt: P43034

Pathways: M Phase, Regulation of Cell Size