UCP2 Antikörper (AA 201-309)

Produktnummer ABIN675428

Produktdetails anti-UCP2 Antikörper

Target: UCP2 (Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2))

Bindungsspezifität: AA 201-309

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Mouse UCP-2 (Mitochondrial intermembrane space domain)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-UCP2 Antikörper (ABIN675428)

Bo, Xie, Guo, Zhang, Guan, Li, Lu, Meng: "Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs." in: Journal of diabetes research, Vol. 2016, pp. 2029854, (2016) (PubMed).

Chuang, Lin, Huang, Chang, Liou, Chen, Chang, Chan et al.: "Peroxisome proliferator-activated receptors ?/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status ..." in: Journal of neuroinflammation, Vol. 9, pp. 184, (2012) (PubMed).

Details zu UCP2

Target: UCP2 (Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2))

Andere Bezeichnung: UCP-2 (UCP2 Produkte)

Synonyme: UCP2 antikoerper, DKFZp470P1633 antikoerper, ucp2 antikoerper, MGC53319 antikoerper, MGC75881 antikoerper, cb74 antikoerper, ATUCP2 antikoerper, K19M22.21 antikoerper, K19M22_21 antikoerper, uncoupling protein 2 antikoerper, BMIQ4 antikoerper, SLC25A8 antikoerper, UCPH antikoerper, Slc25a8 antikoerper, mitochondrial uncoupling protein 2 antikoerper, uncoupling protein 2 antikoerper, uncoupling protein 2 (mitochondrial, proton carrier) L homeolog antikoerper, uncoupling protein 2 (mitochondrial, proton carrier) antikoerper, uncoupling protein 1 antikoerper, PTRG_09289 antikoerper, UCP2 antikoerper, LOC100282746 antikoerper, ucp2.L antikoerper, ucp2 antikoerper, ucp1 antikoerper, Ucp2 antikoerper

Hintergrund:

Synonyms: Slc25a8, Mitochondrial uncoupling protein 2, UCP 2, Solute carrier family 25 member 8, UCPH, Ucp2

Background: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).

Gen-ID: 22228

UniProt: P70406

Pathways: Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Proton Transport