CD45 Antikörper (AA 1210-1304)

Produktnummer ABIN669606

Produktdetails anti-CD45 Antikörper

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Bindungsspezifität: AA 1210-1304

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD45 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Spezifität: The antibody is predicted to work with Mouse and Rat samples, but with decreased sensitivity compared to human samples.

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD45

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CD45 Antikörper (ABIN669606)

Zhu, Meng, Wang, Wang, Zhang, Li, Li, Tan, Yang, Huang: "Effects of neuritin on the differentiation of bone marrow‑derived mesenchymal stem cells into neuron‑like cells." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 3201-3207, (2018) (PubMed).

Liao, Zhong, Liu, Li, Ling, Zou: "Bone mesenchymal stem cells co-expressing VEGF and BMP-6 genes to combat avascular necrosis of the femoral head." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 954-962, (2018) (PubMed).

Tsang, Huang, Yang, Chi, Chiang, Wang, Andocs, Szasz, Li, Chi: "Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy." in: BMC cancer, Vol. 15, pp. 708, (2015) (PubMed).

Gao, Zhang, Ding, Chen, Hu, Jiang, Li, Chen, Wang, Ye, Zhu: "Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells." in: Cell transplantation, Vol. 22, Issue 10, pp. 1883-900, (2014) (PubMed).

Zeng, Hu, Yuan, Hu, Zhong, Kang: "Increased expression of importin13 in endometriosis and endometrial carcinoma." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 18, Issue 6, pp. CR361-7, (2012) (PubMed).

Details zu CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Andere Bezeichnung: CD45 (PTPRC Produkte)

Synonyme: PTPRC antikoerper, si:dkeyp-47c5.1 antikoerper, B220 antikoerper, CD45 antikoerper, CD45R antikoerper, GP180 antikoerper, L-CA antikoerper, LCA antikoerper, LY5 antikoerper, T200 antikoerper, Cd45 antikoerper, Ly-5 antikoerper, Lyt-4 antikoerper, loc antikoerper, Lca antikoerper, RT7 antikoerper, cd45 antikoerper, protein tyrosine phosphatase, receptor type C antikoerper, protein tyrosine phosphatase, receptor type, C antikoerper, receptor-type tyrosine-protein phosphatase C antikoerper, PTPRC antikoerper, ptprc antikoerper, LOC100074271 antikoerper, Ptprc antikoerper

Hintergrund:

Synonyms: LCA, LY5, B220, CD45, L-CA, T2, CD45R, GP18, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, PTPRC

Background: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Gen-ID: 5788

UniProt: P08575

Pathways: T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling