Nav1.8 Antikörper (C-Term)

Produktnummer ABIN6658124

Produktdetails anti-Nav1.8 Antikörper

Target: Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Nav1.8 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Fluorescence Microscopy (FM)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Anti-NAV1.8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.8 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross reactivity against other Nav channels. Cross-reactivity with NAV1.8 from other sources has not been determined. Ion Channels research.

Immunogen:

Immunogen: Nav1.8 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding near the cytoplasmic C-terminus region of rat Nav1.8.

Immunogen Type: Recombinant Protein

Klon: S134-12

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-NAV1.8 Antibody is suitable for use in WB, IHC and IF microscopy. Expect a band approximately ~220 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1-10 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu Nav1.8

Target: Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))

Andere Bezeichnung: NAV1.8 (SCN10A Produkte)

Synonyme: Nav1.8 antikoerper, PN3 antikoerper, SNS antikoerper, hPN3 antikoerper, Na(V)1.8 antikoerper, sodium channel, voltage-gated, type X, alpha antikoerper, sodium voltage-gated channel alpha subunit 10 antikoerper, Scn10a antikoerper, SCN10A antikoerper

Hintergrund:

Synonyms: PN3, Na(V)1.8, Scn10a, Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8

Background: Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.

Gene Name: Scn10a

Gen-ID: 29571

NCBI Accession: NP_058943

UniProt: Q62968