SCN9A Antikörper (C-Term)

Produktnummer ABIN6656787

Produktdetails anti-SCN9A Antikörper

Target: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCN9A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been determined. Channels and Transporters research.

Immunogen:

Immunogen: Nav1.7 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of human Nav1.7.

Immunogen Type: Recombinant Protein

Klon: S68-6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-NAV1.7 Antibody is suitable for use in WB, IP, and IF microscopy. Expect a band approximately ~230 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1-10 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu SCN9A

Target: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Andere Bezeichnung: NAV1.7 (SCN9A Produkte)

Synonyme: SCN9A antikoerper, DKFZp459G084 antikoerper, Nav1.7 antikoerper, PN1 antikoerper, mKIAA4197 antikoerper, Scn2a antikoerper, ETHA antikoerper, FEB3B antikoerper, GEFSP7 antikoerper, NE-NA antikoerper, NENA antikoerper, SFNP antikoerper, sodium channel, voltage-gated, type IX, alpha subunit antikoerper, sodium voltage-gated channel alpha subunit 9 antikoerper, sodium channel protein type 9 subunit alpha antikoerper, sodium channel, voltage-gated, type IX, alpha antikoerper, SCN9A antikoerper, LOC100016648 antikoerper, Scn9a antikoerper

Hintergrund:

Synonyms: ETHA, hNE Na, NENA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1.7, peripheral sodium channel 1, neuroendocrine sodium channel, Sodium channel protein type 9 subunit alpha

Background: Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.

Gene Name: Scn9a

Gen-ID: 6335

NCBI Accession: NP_002968

UniProt: Q15858