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SCN9A Antikörper (AA 1751-1946) (PE)

SCN9A Reaktivität: Human AA, ICC, IF, IHC, IP, WB Wirt: Maus Monoclonal N68-6 (Formerly S68-6) PE
Produktnummer ABIN2483102
$533.00
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle SCN9A Antikörper anzeigen
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Bindungsspezifität
    • 11
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1751-1946
    Reaktivität
    • 50
    • 19
    • 15
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 27
    • 18
    • 7
    • 1
    Maus
    Klonalität
    • 35
    • 18
    Monoklonal
    Konjugat
    • 26
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCN9A Antikörper ist konjugiert mit PE
    Applikation
    • 29
    • 23
    • 18
    • 14
    • 12
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Detects ~230 kDa. No cross-reactivity against other Nav channels.
    Kreuzreaktivität
    Hamster, Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
    Klon
    N68-6 (Formerly S68-6)
    Isotyp
    IgG1
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2483102 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Andere Bezeichnung
    Nav1.7 (SCN9A Produkte)
    Synonyme
    SCN9A, DKFZp459G084, Nav1.7, PN1, mKIAA4197, Scn2a, ETHA, FEB3B, GEFSP7, NE-NA, NENA, SFNP, sodium channel, voltage-gated, type IX, alpha subunit, sodium voltage-gated channel alpha subunit 9, sodium channel protein type 9 subunit alpha, sodium channel, voltage-gated, type IX, alpha, SCN9A, LOC100016648, Scn9a
    Hintergrund
    Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
    Gen-ID
    6335
    NCBI Accession
    NP_002968
    UniProt
    Q15858
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