Synonyms: ARVC 10,ARVC10,ARVD 10,ARVD10,Cadherin family member 5,CDHF 5,CDHF5,CMD1BB,Desmoglein 2,Desmoglein-2,Desmoglein2,DSG 2,DSG2,DSG2,HDGC,HDGC included,Human Desmoglein colon,MGC117034,MGC117036,MGC117037
Background: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.