Desmoglein 2 Antikörper (N-Term)

Produktnummer ABIN2782147

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Desmoglein 2 Antikörper wird verwendet zum Nachweis von Desmoglein 2 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB und IHC.

Kurzübersicht für Desmoglein 2 Antikörper (N-Term) (ABIN2782147)

Target: Desmoglein 2 (DSG2)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoglein 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Desmoglein 2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: DSG2 Antibody - N-terminal region

Sequenz: KIHSDLAEER GLKITYKYTG KGITEPPFGI FVFNKDTGEL NVTSILDREE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DSG2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DSG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45198-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Desmoglein 2 Antikörper (ABIN2782147)

Hummitzsch, Irving-Rodgers, Hatzirodos, Bonner, Sabatier, Reinhardt, Sado, Ninomiya, Wilhelm, Rodgers: "A new model of development of the mammalian ovary and follicles." in: PLoS ONE, Vol. 8, Issue 2, pp. e55578, (2013) (PubMed).

Details zu Desmoglein 2

Target: Desmoglein 2 (DSG2)

Andere Bezeichnung: DSG2

Hintergrund:

Background Information: Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. DSG2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Desmoglein 2

Alternative Symbols: HDGC, CDHF5

Protein Name: Desmoglein-2

Molekulargewicht: 114 kDa

Gen-ID: 1829

NCBI Accession: NP_001934

UniProt: Q14126

Pathways: Cell-Cell Junction Organization