BCCIP Antikörper

Produktnummer ABIN6571857

Produktdetails anti-BCCIP Antikörper

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCCIP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human BCCIP (NP_510868.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Andere Bezeichnung: BCCIP (BCCIP Produkte)

Synonyme: zgc:110272 antikoerper, mp:zf637-1-000774 antikoerper, BCCIP antikoerper, DKFZp459K2416 antikoerper, MGC82792 antikoerper, tok-1 antikoerper, MGC89311 antikoerper, TOK-1 antikoerper, TOK1 antikoerper, 1110013J05Rik antikoerper, BRCA2 and CDKN1A interacting protein antikoerper, BRCA2 and CDKN1A interacting protein L homeolog antikoerper, BCCIP antikoerper, bccip antikoerper, bccip.L antikoerper, Bccip antikoerper

Hintergrund: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Molekulargewicht:

Observed_MW: 50kDa

Calculated_MW: 33kDa/35kDa/36kDa

Gen-ID: 56647

UniProt: Q9P287