AFT1 Antikörper

Produktnummer ABIN5962899

Produktdetails anti-AFT1 Antikörper

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human ATF1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu AFT1

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Andere Bezeichnung: ATF1 (AFT1 Produkte)

Synonyme: ews-atf1 antikoerper, fus/atf-1 antikoerper, treb36 antikoerper, ATF1 antikoerper, EWS-ATF1 antikoerper, FUS/ATF-1 antikoerper, TREB36 antikoerper, Atf-1 antikoerper, wu:fc92c07 antikoerper, zgc:64099 antikoerper, activating transcription factor 1 antikoerper, activating transcription factor 1 L homeolog antikoerper, atf1 antikoerper, ATF1 antikoerper, MGC85066 antikoerper, atf1.L antikoerper, Atf1 antikoerper

Hintergrund:

Synonyms: Activating transcription factor 1,ATF 1,atf1,ATF1 EWS fusion gene,ATF1 FUS fusion gene,ATF1,cAMP dependent transcription factor 1,cAMP-dependent transcription factor ATF-1,Cyclic AMP dependent transcription factor ATF 1,Cyclic AMP dependent transcription factor ATF1,Cyclic AMP-dependent transcription factor ATF-1,EWS AFT1,FUS ATF 1,FUS/ATF 1,Protein TREB36,RNA binding protein activating transcription factor 1 fusion protein,TREB 36,TREB36,TREB36 protein

Background: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Molekulargewicht:

Observed_MW: 27-36kDa

Calculated_MW: 15kDa/29kDa

Gen-ID: 466

UniProt: P18846

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades