Synonyms: CD16,CD16b,CD16b antigen ,Fc fragment of IgG low affinity IIIb receptor,Fc gamma receptor IIIb,Fc gamma RIII,Fc gamma RIII beta,Fc gamma RIIIb,Fc-gamma RIII,Fc-gamma RIII-beta,Fc-gamma RIIIb,FCG3,FCG3B,FCGR3,FCGR3B,FcR 10,FcR-10,FcR10,FcRIII,FcRIIIb,IGFR3,IgG Fc receptor III 1,IgG Fc receptor III-1,Low affinity immunoglobulin gamma Fc region receptor III B,Low affinity immunoglobulin gamma Fc region receptor III-B
Background: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.