SH2D1A Antikörper

Produktnummer ABIN6567141

Produktdetails anti-SH2D1A Antikörper

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SH2D1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A (SH2D1A Produkte)

Synonyme: DSHP antikoerper, EBVS antikoerper, IMD5 antikoerper, LYP antikoerper, MTCP1 antikoerper, SAP antikoerper, SAP/SH2D1A antikoerper, XLP antikoerper, XLPD antikoerper, RGD1562408 antikoerper, Gm686 antikoerper, SH2D1A antikoerper, SH2 domain containing 1A antikoerper, SH2D1A antikoerper, Sh2d1a antikoerper

Hintergrund:

Synonyms: DSHP,Duncan disease SH2 protein,Duncan disease SH2-protein,EBVS,IMD5,LYP,MTCP1,SAP,SAP/SH2D1A,SH2 domain containing 1A,SH2 domain protein 1A,SH2 domain-containing protein 1A,SH21A,SH2D1A,Signaling lymphocyte activation molecule associated protein,Signaling lymphocytic activation molecule-associated protein,SLAM associated protein,SLAM associated protein/SH2 domain protein 1A,SLAM-associated protein,T cell signal transduction molecule SAP,T-cell signal transduction molecule SAP,XLP,XLPD

Background: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 17kDa

Calculated_MW: 6kDa/8kDa/13kDa/14kDa

Gen-ID: 4068

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process