SH2D1A Produkte
(SH2 Domain Containing 1A (SH2D1A))
Kategorien
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte SH2D1A Kategorien
SH2D1A Antikörper
High quality antibodies with extensive validation data.
SH2D1A ELISA Kits
Reliable ELISA kits for a wide range of species.
SH2D1A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SH2D1A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (5)
- (4)
Kat. Nr.
ABIN561703
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN3021536
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (2)
Kat. Nr.
ABIN7169449
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene SH2D1A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4884511
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6386237
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SH2D1A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125076
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1319861
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3132254
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SH2D1A Produkten
: "Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 4915-24, (2016) (PubMed).: "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1149-61, (2014) (PubMed).
: "Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 6, pp. 1381-1387.e7, (2014) (PubMed).
: "Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus." in: The Journal of experimental medicine, Vol. 209, Issue 5, pp. 913-24, (2012) (PubMed).
: "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP." in: PLoS biology, Vol. 9, Issue 11, pp. e1001187, (2011) (PubMed).
: "Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12." in: Immunology and cell biology, Vol. 87, Issue 8, pp. 590-600, (2009) (PubMed).
: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).
: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." in: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
Synonyme und alternative Namen zu SH2D1A
SH2 domain containing 1A (SH2D1A), SH2 domain containing 1A (Sh2d1a), DSHP, EBVS, Gm686, IMD5, LYP, MTCP1, RGD1562408, SAP, SAP/SH2D1A, SH2D1A, XLP, XLPDBezeichner auf Proteinebene für SH2D1A
- Duncan disease SH2-protein
- SH2 domain-containing protein 1A
- SLAM associated protein/SH2 domain protein 1A
- SLAM-associated protein
- T cell signal transduction molecule SAP
- T-cell signal transduction molecule SAP
- signaling lymphocyte activation molecule-associated protein
- signaling lymphocytic activation molecule-associated protein
- SH2 domain protein 1A
- SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
- Signaling lymphocytic activation molecule-associated protein
- Duncan disease homolog
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