CBL Antikörper
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- Target Alle CBL Antikörper anzeigen
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CBL Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human CBL (NP_005179.2).
- Isotyp
- IgG
- Top Product
- Discover our top product CBL Primärantikörper
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- Applikationshinweise
- IHC 1:50-1:100 IF 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
- Andere Bezeichnung
- CBL (CBL Produkte)
- Synonyme
- 4732447J05Rik antikoerper, Cbl-2 antikoerper, c-Cbl antikoerper, cbl antikoerper, C-CBL antikoerper, CBL2 antikoerper, FRA11B antikoerper, NSLL antikoerper, RNF55 antikoerper, c-cbl-like antikoerper, RGD1561386 antikoerper, Casitas B-lineage lymphoma antikoerper, Cbl proto-oncogene antikoerper, Cbl antikoerper, CBL antikoerper
- Hintergrund
- This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
- Molekulargewicht
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Observed_MW: 115-130kDa
Calculated_MW: 99kDa
- Gen-ID
- 867
- UniProt
- P22681
- Pathways
- T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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