This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This STARD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-215 amino acids from the C-terminal region of human STARD6.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
LaVoie, Whitfield, Shi, King, Bose, Hui: "STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis." in: Experimental biology and medicine (Maywood, N.J.), Vol. 239, Issue 4, pp. 430-5, (2014) (PubMed).
Target
STARD6
(StAR-Related Lipid Transfer (START) Domain Containing 6 (STARD6))
1700011K09Rik antikoerper, 4833424I06Rik antikoerper, 4933429L05Rik antikoerper, AI644424 antikoerper, StAR related lipid transfer domain containing 6 antikoerper, StAR-related lipid transfer (START) domain containing 6 antikoerper, STARD6 antikoerper, Stard6 antikoerper
Hintergrund
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1, MIM 184756) and by liver X receptors (e.g., LXRA, MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR, MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).