RFWD2 Antikörper (N-Term)

Produktnummer ABIN655275

Produktdetails anti-RFWD2 Antikörper

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Bindungsspezifität: AA 37-65, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFWD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1.

Klon: RB19572

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu RFWD2

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Andere Bezeichnung: COP1 (RFWD2 Produkte)

Synonyme: COP1 antikoerper, RNF200 antikoerper, AI316802 antikoerper, C80879 antikoerper, Cop1 antikoerper, RGD1304773 antikoerper, RFWD2 antikoerper, cop1 antikoerper, rnf200 antikoerper, zgc:163067 antikoerper, ring finger and WD repeat domain 2 antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog antikoerper, RFWD2 antikoerper, Rfwd2 antikoerper, rfwd2 antikoerper, rfwd2.L antikoerper

Hintergrund: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Molekulargewicht: 22625

Gen-ID: 114769

NCBI Accession: NP_001017534, NP_443121

UniProt: Q5EG05

Pathways: Photoperiodism