RFWD2 Antikörper (C-Term)

Produktnummer ABIN1881747

Produktdetails anti-RFWD2 Antikörper

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Bindungsspezifität: AA 672-701, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFWD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RFWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of human RFWD2.

Klon: RB41831

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RFWD2 Antikörper (ABIN1881747)

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Li, Ohshiro, Reddy, Pakala, Lee, Zhang, Rayala, Kumar: "E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 41, pp. 17493-8, (2009) (PubMed).

Kato, Ding, Pisck, Jhala, Du: "COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35464-73, (2008) (PubMed).

Details zu RFWD2

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Andere Bezeichnung: RFWD2 (RFWD2 Produkte)

Synonyme: COP1 antikoerper, RNF200 antikoerper, AI316802 antikoerper, C80879 antikoerper, Cop1 antikoerper, RGD1304773 antikoerper, RFWD2 antikoerper, cop1 antikoerper, rnf200 antikoerper, zgc:163067 antikoerper, ring finger and WD repeat domain 2 antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase antikoerper, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog antikoerper, RFWD2 antikoerper, Rfwd2 antikoerper, rfwd2 antikoerper, rfwd2.L antikoerper

Hintergrund: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Molekulargewicht: 80474

NCBI Accession: NP_001001740, NP_071902

UniProt: Q8NHY2

Pathways: Photoperiodism