Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) (AA 63-90), (N-Term) Antikörper

Details zu Produkt Nr. ABIN654602, Anbieter: Anmelden zum Anzeigen
Antigen
  • GEFSP1
  • sodium channel, voltage-gated, type I, beta
  • sodium voltage-gated channel beta subunit 1
  • Scn1b
  • SCN1B
Epitop
AA 63-90, N-Term
21
9
9
2
1
1
1
Reaktivität
Human, Maus
64
48
37
5
3
3
3
2
1
1
1
Wirt
Kaninchen
64
Klonalität (Klon)
Polyklonal ()
Konjugat
Unkonjugiert
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
39
20
19
17
13
9
4
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 AA from the N-terminal region of human SCN1B.
Klon RB22198
Isotyp Ig Fraction
Homologie Cow (Bovine),Rat (Rattus),Rabbit
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung SCN1B (SCN1B Antibody Abstract)
Hintergrund Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: SCN1B,Sodium channel subunit beta-1,
Molekulargewicht 24707 Da
Gen-ID 6324
NCBI Accession NP_001028, NP_950238
UniProt Q07699
Applikationshinweise Suggested dilutions:
WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung Avoid freeze-thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) (AA 63-90), (N-Term) antibody (ABIN654602) SCN1B Antibody (N-Term) western blot analysis in mouse Neuro-2a cell line lysates (3...
Immunohistochemistry (IHC) image for anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) (AA 63-90), (N-Term) antibody (ABIN654602) SCN1B Antibody (N-Term) immunohistochemistry analysis in formalin fixed and paraffin...
Flow Cytometry (FACS) image for anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) (AA 63-90), (N-Term) antibody (ABIN654602) SCN1B Antibody (N-Term) flow cytometric analysis of Hela cells (right histogram) com...
Allgemeine Veröffentlichungen Grover, Gourie-Devi, Baghel, Sharma, Bala, Gupta, Narayanasamy, Varma, Gupta, Kaur, Talwar, Kaur, Giddaluru, Sharma, Brahmachari, Indian Genome Variation Consortium, Kukreti: "Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment." in: Pharmacogenomics, Vol. 11, Issue 7, pp. 927-41, 2010 (PubMed).

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