This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.
GEFSP1 antikoerper, sodium channel, voltage-gated, type I, beta antikoerper, sodium voltage-gated channel beta subunit 1 antikoerper, Scn1b antikoerper, SCN1B antikoerper
Hintergrund
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.