Protocadherin gamma Subfamily C, 3 (PCDHGC3) (AA 511-539) Antikörper

Produktnummer ABIN654100

Produktdetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Bindungsspezifität: AA 511-539

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PCDHGC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-539 amino acids from the Central region of human PCDHGC3.

Klon: RB22247

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Andere Bezeichnung: PCDHGC3 (PCDHGC3 Produkte)

Synonyme: PC43 antikoerper, PCDH-GAMMA-C3 antikoerper, PCDH2 antikoerper, Pcdh2 antikoerper, PCDHGA11 antikoerper, PCDHGC5 antikoerper, protocadherin gamma subfamily C, 3 antikoerper, PCDHGC3 antikoerper, Pcdhgc3 antikoerper

Hintergrund: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molekulargewicht: 101077

Gen-ID: 5098

NCBI Accession: NP_002579, NP_115778

UniProt: Q9UN70