Protocadherin gamma Subfamily C, 3 (PCDHGC3) (AA 518-547), (Middle Region) Antikörper

Produktnummer ABIN954050

Produktdetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Bindungsspezifität: AA 518-547, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes PCDHGC3.

Aufreinigung: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 518-547aa) of human PCDHGC3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Antigendetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Andere Bezeichnung: PCDHGC3 (PCDHGC3 Produkte)

Synonyme: PC43 antikoerper, PCDH-GAMMA-C3 antikoerper, PCDH2 antikoerper, Pcdh2 antikoerper, PCDHGA11 antikoerper, PCDHGC5 antikoerper, protocadherin gamma subfamily C, 3 antikoerper, PCDHGC3 antikoerper, Pcdhgc3 antikoerper

Hintergrund: The PCDHGC3 gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.Synonyms: PC-43, PC43, PCDH-gamma-C3, PCDH2, Protocadherin 2, Protocadherin 43, Protocadherin gamma-C3, Protocadherin-2, Protocadherin-43

Molekulargewicht: 101077 Da

Gen-ID: 5098

NCBI Accession: NP_002579