GRP78 Antikörper (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)) (AA 541-568)

Details for Product anti-HSPA5 Antibody No. ABIN651231, Anbieter: Anmelden zum Anzeigen
Antigen
  • GRP78
  • BiP
  • GRP-78
  • grp78
  • hspa5a
  • BIP
  • MIF2
  • AL022860
  • AU019543
  • Bip
  • D2Wsu141e
  • D2Wsu17e
  • Grp78
  • Hsce70
  • SEZ-7
  • Sez7
  • baffled
  • mBiP
  • cb865
  • fb60h09
  • fi36d04
  • wu:fb60h09
  • wu:fi36d04
  • zgc:55994
  • zgc:77606
  • 78 kDa glucose-regulated protein
  • heat shock protein family A (Hsp70) member 5
  • BiP/GRP78
  • glucose-regulated protein 78
  • putative glucose-regulated protein 78
  • Hsp70 family ATPase KAR2
  • heat shock protein family A (Hsp70) member 5 S homeolog
  • heat shock 70 kDa protein 5a
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
  • heat shock protein 5
  • heat shock protein family A member 5
  • CpipJ_CPIJ003550
  • HSPA5
  • grp78
  • LOC100533358
  • BiP/grp78
  • Tc00.1047053506585.40
  • Tb11.02.5450
  • Tb11.02.5500
  • LMJF_28_1200
  • KAR2
  • LOC100135840
  • hspa5.S
  • hspa5
  • Hspa5
Epitop
AA 541-568, C-Term
61
41
29
26
24
21
11
11
10
10
7
5
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
509
331
306
65
65
63
61
61
58
54
31
15
14
7
4
3
3
3
2
2
1
1
1
1
Wirt
Kaninchen
295
220
8
6
3
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser GRP78 Antikörper ist unkonjugiert
32
27
21
17
17
15
13
11
11
11
11
11
11
11
11
11
8
8
8
8
8
7
7
7
7
5
4
4
4
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
495
251
235
227
148
60
34
27
13
13
11
7
6
6
3
3
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-568 AA from the C-terminal region of human HSPA5.
Klon RB20814
Isotyp Ig Fraction
Spezifität This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-587 amino acids from the C-terminal region of human HSPA5.
Homologie Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus),Xenopus laevis
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung HSPA5 (HSPA5 Antibody Abstract)
Hintergrund When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
Synonyms: HSPA5,GRP78,78 kDa glucose-regulated protein
Molekulargewicht 72333 DA
Gen-ID 3309
NCBI Accession NP_005338
UniProt P11021
Forschungsgebiet Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Pathways Thyroid Hormone Synthesis, ER-Nucleus Signaling
Applikationshinweise WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 541-568), (C-Term) antibody (ABIN651231) HSPA5 Antibody (C-term) (ABIN651231) western blot analysis in A375,A2058,Hela cell li...
Immunohistochemistry (IHC) image for anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 541-568), (C-Term) antibody (ABIN651231) HSPA5 Antibody (C-term) (ABIN651231) immunohistochemistry analysis in formalin fixed ...
Flow Cytometry (FACS) image for anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 541-568), (C-Term) antibody (ABIN651231) HSPA5 Antibody (C-term) (ABIN651231) flow cytometric analysis of Hela cells (right hi...
Allgemeine Veröffentlichungen Zhuang, Scolyer, Murali, McCarthy, Zhang, Thompson, Hersey: "Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 1, pp. 45-53, 2010 (PubMed).

Zhao, Zhang, Tian, Fang, Lu, Yuan, Yang, Wen: "Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis." in: Journal of medical virology, Vol. 82, Issue 1, pp. 14-22, 2009 (PubMed).

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