APPL2 Antikörper
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- Target Alle APPL2 Antikörper anzeigen
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APPL2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein of human APPL2
- Isotyp
- IgG
- Top Product
- Discover our top product APPL2 Primärantikörper
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- Applikationshinweise
- WB 1:500 - 1:2000
- Kommentare
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High levels in brain, heart, kidney and skeletal muscle
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Andere Bezeichnung
- APPL2 (APPL2 Produkte)
- Synonyme
- RGD1563028 antikoerper, MGC84621 antikoerper, dip13b antikoerper, APPL2 antikoerper, DIP13B antikoerper, Dip3b antikoerper, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 antikoerper, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog antikoerper, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 antikoerper, Appl2 antikoerper, APPL2 antikoerper, appl2.L antikoerper, appl2 antikoerper
- Hintergrund
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12,22)(q24.1,q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
- Molekulargewicht
- 74.493 kDa
- Gen-ID
- 55198
- UniProt
- Q8NEU8
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