APPL2 Produkte
(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
Kategorien
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].
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Ausgewählte APPL2 Kategorien
APPL2 Antikörper
High quality antibodies with extensive validation data.
APPL2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene APPL2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN527414
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (4)
Kat. Nr.
ABIN527415
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IF, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7149505
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene APPL2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964611
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene APPL2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121696
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345410
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345412
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren APPL2 Produkten
: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." in: The European journal of neuroscience, (2019) (PubMed).: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." in: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).
: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." in: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).
: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." in: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).
Synonyme und alternative Namen zu APPL2
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028Bezeichner auf Proteinebene für APPL2
- DCC-interacting protein 13-beta
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- amyloid beta (A4) precursor-like protein 2
- DIP13 beta
- adapter protein containing PH domain, PTB domain and leucine zipper motif 2
- Dip3 beta
- dip13-beta
Haben Sie etwas anderes gesucht?
- APPL1
- APPBP2
- APP (Aducanumab Biosimilar)
- APP
- Apotransferrin
- Apoptotic Neutrophils
- Apoptosis Protease Activating Factor 1
- Apoptosis Inhibitor 5
- APOPT1
- Apoprotein A1
- APOOL
- Apolipoprotein O
- Apolipoprotein M
- Apolipoprotein L 5
- Apolipoprotein L 4
- Apolipoprotein L 2
- Apolipoprotein F
- Apolipoprotein D
- Apolipoprotein C-II
- Apolipoprotein A-I
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