Granulin Antikörper

Produktnummer ABIN6292502

Produktdetails anti-Granulin Antikörper

Target: Granulin (GRN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human GRN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Kommentare:

In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines, Present in inflammatory cells and bone marrow, Highest levels in kidney

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: GRN (GRN Produkte)

Synonyme: GRN antikoerper, grn antikoerper, wu:fb11g12 antikoerper, wu:fj18f05 antikoerper, MGC53354 antikoerper, DKFZp459H066 antikoerper, CLN11 antikoerper, GEP antikoerper, GP88 antikoerper, PCDGF antikoerper, PEPI antikoerper, PGRN antikoerper, epithelin antikoerper, acrogranin antikoerper, granulin precursor antikoerper, granulin a antikoerper, Granulins antikoerper, granulin L homeolog antikoerper, granulin antikoerper, GRN antikoerper, grna antikoerper, grn antikoerper, grn.L antikoerper, granulin antikoerper, ORF1 granulin antikoerper, Grn antikoerper

Substanzklasse: Viral Protein

Hintergrund: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Molekulargewicht: 63.544 kDa

Gen-ID: 2896

UniProt: P28799